I have a 2014 E350 and just bought a Genesis 3.8. I am more than impressed with the Genesis. I'll try to start a list of differences, some tiny and some subjective, but I figure visitors to this forum want it all 
I love how when I walk up to the car at night, it greats me. E doesn't do that.
Genesis seems quieter.
Genesis radio is much easier to operate and very well integrated.
BlueLink for $179 a year is much better value than MBrace which if $500+
Genesis can be remote started, the E can't.
The App on Genesis does more than MB which other than unlocking the doors doesn't do anything.
The ride is plusher on the Genesis. MB is a bit more sporty.
The MB seems more planted, but that's probably because the suspension is stiffer.
E does not offer electric folding side mirrors.
Steering feels the same to me.
The MB will drive itself on the highway. It bitches if going more than 25mph and you leave your hands off the wheel.
MB lane departure warning works a little bit better.
MB blind spot operates at lower speeds and is much better. MB shows clear, not sure or blocked. G shows only not sure or blocked at only at higher speeds.
Auto Parking. I don't have this on my G, but on the E it is excellent. It will parallel park and back into spaces.
Surround View. The E is great. I don't have it on my G.
The E has better visibility from the rear and I don't hit my head on the door when I get into it. The G seems more raked in the front.
The Genesis will move the seat back if you want. I need that so I don't bump my head.
Trunk. The E wins here. I would prefer to wave my foot under the trunk. My key might be in the car. I don't like the G beeping when I walk behind it. The E is power up and down. The G just pops open. The E trunk is smaller, but the seats go down.
HVAC. The E has the best controls around and Auto knows just what to do. The G is fine and I have to problem operating it.
Radio. The E has a poor user interface. I would give the G a B+. Sound wise I think they are both excellent.
Voice. The E has very poor voice recognition. The G is better but so far not as good as UVO. I haven't fully researched the proper use. My salesman says it learns, but I doubt that.
Navigation. The E feels a bit dated. I love the way the G operates. Really outstanding. The screen size is just right. Not too big or small and the instructions in the instrument panel are perfect.
Center LCD. I think I'd give the E an A and the G a B here. The E has a lot more flexibility on what is displayed. The G on the other hand is much easier to change what is displayed.
Seats. Both are very comfortable. The E is firmer. The G are a little softer and larger. I don't have advanced seating on either car.
Engine & Tranny. Both cars are very smooth shifting. And both have plenty of power to merge. The G has 8 speeds, the E, 7.
Key Less Go. The E wins here. You just walk up and pull the handle. You don't have to push a button and any door can be used. On the E the button is used only to lock the car.
The E seems to have a longer service interval. 1 year or 15K miles.
Visibility. The E has a better view through the rear window.
Mirror. I only mention this because the G has a rather cheap looking mirror with that stupid compass in the corner. You can turn off the compass, but you have to do each time.
ECO. The E starts and stops the engine to save engine. Many people hate that and disable it every time they start the car. I'm neutral. I can take it or leave it.
Summary. I think had the Ultimate been out when I bought my E a year ago, I would have gotten it. The plusher and quiet ride, good looks and great user interface inside make it for me.

I love how when I walk up to the car at night, it greats me. E doesn't do that.
Genesis seems quieter.
Genesis radio is much easier to operate and very well integrated.
BlueLink for $179 a year is much better value than MBrace which if $500+
Genesis can be remote started, the E can't.
The App on Genesis does more than MB which other than unlocking the doors doesn't do anything.
The ride is plusher on the Genesis. MB is a bit more sporty.
The MB seems more planted, but that's probably because the suspension is stiffer.
E does not offer electric folding side mirrors.
Steering feels the same to me.
The MB will drive itself on the highway. It bitches if going more than 25mph and you leave your hands off the wheel.
MB lane departure warning works a little bit better.
MB blind spot operates at lower speeds and is much better. MB shows clear, not sure or blocked. G shows only not sure or blocked at only at higher speeds.
Auto Parking. I don't have this on my G, but on the E it is excellent. It will parallel park and back into spaces.
Surround View. The E is great. I don't have it on my G.
The E has better visibility from the rear and I don't hit my head on the door when I get into it. The G seems more raked in the front.
The Genesis will move the seat back if you want. I need that so I don't bump my head.
Trunk. The E wins here. I would prefer to wave my foot under the trunk. My key might be in the car. I don't like the G beeping when I walk behind it. The E is power up and down. The G just pops open. The E trunk is smaller, but the seats go down.
HVAC. The E has the best controls around and Auto knows just what to do. The G is fine and I have to problem operating it.
Radio. The E has a poor user interface. I would give the G a B+. Sound wise I think they are both excellent.
Voice. The E has very poor voice recognition. The G is better but so far not as good as UVO. I haven't fully researched the proper use. My salesman says it learns, but I doubt that.
Navigation. The E feels a bit dated. I love the way the G operates. Really outstanding. The screen size is just right. Not too big or small and the instructions in the instrument panel are perfect.
Center LCD. I think I'd give the E an A and the G a B here. The E has a lot more flexibility on what is displayed. The G on the other hand is much easier to change what is displayed.
Seats. Both are very comfortable. The E is firmer. The G are a little softer and larger. I don't have advanced seating on either car.
Engine & Tranny. Both cars are very smooth shifting. And both have plenty of power to merge. The G has 8 speeds, the E, 7.
Key Less Go. The E wins here. You just walk up and pull the handle. You don't have to push a button and any door can be used. On the E the button is used only to lock the car.
The E seems to have a longer service interval. 1 year or 15K miles.
Visibility. The E has a better view through the rear window.
Mirror. I only mention this because the G has a rather cheap looking mirror with that stupid compass in the corner. You can turn off the compass, but you have to do each time.
ECO. The E starts and stops the engine to save engine. Many people hate that and disable it every time they start the car. I'm neutral. I can take it or leave it.
Summary. I think had the Ultimate been out when I bought my E a year ago, I would have gotten it. The plusher and quiet ride, good looks and great user interface inside make it for me.
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